PIRIV is used to treat certain stomach and esophagus problems (such as acid reflux). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. PIRIV belongs to a class of drugs known as proton pump inhibitors (PPIs).
The mechanism of action of pantoprazole is to inhibit the final step in gastric acid production. In the gastric parietal cell of the stomach, pantoprazole covalently binds to the H+/K+ ATP pump to inhibit gastric acid and basal acid secretion. The covalent binding prevents acid secretion of up to 24 hours and longer.
Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. It is usually given with a prokinetic drug because of inactivity in the acidic environment of the stomach. Pantoprazole binds irreversibly to H+K+ATPase (proton pumps) to suppress the secretion of acid. Due to irreversible binding of the pumps, new pumps have to be made before acid production can be resumed. The drug’s plasma half-life is about 2 hours.
The more common side effects that can occur with pantoprazole include:
- stomach pain
- nausea or vomiting
- joint pain
Pantoprazole oral tablet can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Examples of drugs that can cause interactions with pantoprazole are listed below.
Taking certain HIV drugs with pantoprazole is not recommended. Pantoprazole may significantly decrease the amount of these drugs in your body. This can reduce their ability to control HIV infection. These drugs are:
Some people taking warfarin with pantoprazole can experience increases in INR and prothrombin time (PT). This can lead to an increased risk of severe bleeding. If you take these drugs together, your doctor should monitor you for increases in INR and PT.
Drugs affected by stomach pH
Pantoprazole affects stomach acid levels. As a result, it can reduce your body’s absorption of certain drugs that are sensitive to the effects of decreased stomach acid. This effect can make these drugs less effective.
Examples of these drugs include:
- iron salts
- mycophenolate mofetil
Taking methotrexate with pantoprazole may increase the amount of methotrexate in your body. If you’re taking high doses of methotrexate, your doctor may have you stop taking pantoprazole during your methotrexate therapy.
Packing Available: 1 strip of 10 Tablets
SAFE IN PREGNANCY IN ADEQUATE DOSES
Date of Product Launch: 2013
MRP: Pl. refer price list
PRODUCT QUALITY FEEDBACK : firstname.lastname@example.org
ADVERSE EVENT REPORTING : http://adr.sarp.ltd or email@example.com
TM: Trademark under registration
DISCLAIMER: Product PIRIV has been moved from its previous page http://sarppharmaceuticals.in/capital/piriv to this page
SOURCES: Wikipedia, Webmd, Healthline