Presenting the Safest Anti-Diarrhoeal therapy in its segment…..

Genuver 2 billions/5 ml is a treatment product for oral use that contains a single active ingredient, namely polyantibiotic-resistant spores of B. clausii. It is provided in the form of a suspension containing 2 billion spores per 5 ml. The spores belong to 4 strains (O/C, T, N/R, and SIN) that are resistant to different classes of antibiotics. B. clausii is an aerobic, spore-forming bacterium that is able to inhibit the growth of pathogens in the gastrointestinal tract via three distinct mechanisms: colonization of free ecological niches, which are no longer available for the growth of other microorganisms; competition for epithelial cell adhesion, which is particularly relevant for spores in the initial or intermediate germination phase; production of antibiotics and/or enzymes secreted into the intestinal environment, especially peptide antibiotics, which are mainly active on Gram-positive bacteria, but also enzymes that exhibit lytic activity against Pseudomonas aeruginosa. The B. clausii of Genuver has proven to be highly resistant to gastric acidity and most antibiotics & is safest to be used even on paediatric patients.

ABOUT Bacillus Clausii:

Bacillus clausii is an aerobic, spore-forming bacterium that is able to survive transit through the acidic environment of the stomach and colonize the intestine even in the presence of antibiotics. B. clausii is available for oral use as a suspension of 2 billion spores per 5 mL.


Mechanism of Action:

B. clausii can inhibit the growth of pathogens in the gastrointestinal tract via three distinct mechanisms : colonization of free ecological niches, which are no longer available for the growth of other microorganisms; competition for epithelial cell adhesion, which is particularly relevant for spores in the initial or intermediate germination phase; production of antibiotics and/or enzymes secreted into the intestinal environment, especially peptide antibiotics, which are mainly active on Gram-positive bacteria, but also enzymes that exhibit lytic activity against Pseudomonas aeruginosa. B. clausii also possess antimicrobial and immunomodulatory activities. B. clausii strains were found to release antimicrobial substances in the medium. The release of the antimicrobial substances was observed during stationary growth phase and coincided with sporulation. These substances were active against Gram-positive bacteria, in particular against Staphylococcus aureus, Enterococcus faecium, and Clostridium difficile. The antimicrobial activity was resistant to subtilisin, proteinase K, and chymotrypsin treatment, whereas it was sensitive to pronase treatment. The evaluation of the immunomodulatory properties of B. clausii strains was performed in vitro on Swiss and C57 Bl/6j murine cells. B. clausii strains, in their vegetative forms, were able to induce NOS II synthetase activity, IFN-γ production, and CD4+T-cell proliferation.

The conclusions one can draw from the aforementioned studies is that B. clausii is an effective probiotic and the probiotic of choice in the treatment of diarrhoea, prevention of antibiotic associated diarrhoea and in the prevention of side effects associated with Helicobacter pylori treatment. It has the added advantage of being a spore forming probiotic making it a very resilient, stable probiotic which can be stored at room temperature.


Side effects:

This product belong to safest category for both adults & children. However in extreme rare cases, patient may experience temporary taste distortion, loss of appetite, nausea, vomiting, epigastric pain & bloating.


Dosage:

Adults: 2-3 mini bottles/day

Children: 1-2 mini bottles/day

Infants: 1 mini bottle/day


M.R.P.: Pls refer price list